Download PDF Summer Bridge on Advanced Biomanufacturing for Medicines June 16, 2025 Volume 55 Issue 2 This issue of The Bridge features cutting-edge perspectives on the rapid progress and innovation in advanced biomanufacturing for medicines. Articles In This Issue President's Perspective: The Importance of Engineering and the NAE Monday, June 16, 2025 AuthorJohn L. Anderson Election to the National Academy of Engineering (NAE) is a great honor for any engineer. Yet, the purpose of our organization is not primarily honorific. The NAE exists to serve: to advance the welfare and prosperity of the nation by providing independent advice on matters involving engineering and ... Guest Editors' Introduction: Advanced Biomanufacturing for Medicines Monday, June 16, 2025 AuthorBarry C. Buckland and Kelvin H. Lee In the fall of 2013, Professors Phillip A. Sharp and Robert Langer guest edited an issue of The Bridge on the theme of the Convergence of Engineering and the Life Sciences. The collection forecast the breadth in manufacturing approaches, capabilities, and innovation that would define the ... Transforming Manufacturing to Continue Leading the Innovation of Biopharmaceuticals Monday, June 16, 2025 AuthorJ. Christopher Love Maintaining US leadership in the biomanufacturing sector requires investment in groundbreaking biomanufacturing technologies. Biopharmaceuticals have become essential medicines for preventing and treating diseases ranging from cancer and autoimmune disorders to neurological conditions, ... Biopharmaceutical Manufacturing Platforms: Breaking Away from Our Past Monday, June 16, 2025 AuthorPaul C. Collins The new era of creativity and diversity of treatment modality in the biopharmaceutical industry has accelerated the need to adopt new platforms. “Platform” is a term that is often used in the biopharmaceutical manufacturing industry, but with different connotations and intentions ... NIST Biomanufacturing Reference Materials: Development, Applications, and Impact Monday, June 16, 2025 AuthorKatharina S. Yandrofski, Megan H. Cleveland, Zvi Kelman, Mike J. Tarlov, and John P. Marino The NIST Biomanufacturing Program has made significant progress in antibody manufacturing and provides an approach to analytical measurements that can expedite the time to market of life-saving products and enable broader access to them. Monoclonal antibody (mAb) therapeutics, currently the ... An Open-Access Platform: A NIIMBL Approach to Gene Therapy for Rare Diseases Friday, June 13, 2025 AuthorChris Williams, Eric Hacherl, Tim Charlebois, Erik Barton, Stephen Kaminsky, Brenna Kelley-Clarke, Angie Snell Bennett, Marco Th A promising model for gene therapy development is outlined that supports a thriving gene therapy community and increases access to therapies, particularly for patients with rare and ultra-rare diseases. Developing gene therapies for rare diseases faces significant challenges, including high ... Shaping Future Supply Chains with Bioindustrial Manufacturing Friday, June 13, 2025 AuthorMelanie Tomczak and Penny Norquist Leveraging cutting-edge bioindustrial manufacturing technologies will enhance domestic supply chain resilience. From natural disasters and cyberattacks to growing sociopolitical tensions around the world, global supply chains are more unstable than any time in recent history. This instability ... Revitalizing US Biomanufacturing to Strengthen the Global Supply and Security of Antibiotics Friday, June 13, 2025 AuthorMisti Ushio and Barry C. Buckland Renewed US investment in domestic antibiotic production is essential to ensure supply chain resilience and safeguard global health security. Antibiotics have significantly improved life expectancy and overall public health for over 80 years. The primary reasons antibiotics are critical for human ... Synthetic Biology's Impact on Biopharmaceutical Manufacturing Friday, June 13, 2025 AuthorMruthula Rammohan, Akash Vaidya, Spencer Grissom, Rachel Silvestri, Christopher Pirner, Kevin Solomon, and Mark Blenner There is great potential for synthetic biology to improve biopharmaceutical manufacturing, but fully unleashing it requires technical innovation and solutions that address ethical, legal, security, and societal implications. Synthetic biology has already shown its usefulness in biopharmaceutical ... Revolutionizing National STEM Education to BUILD a Future-Ready Workforce Thursday, June 12, 2025 AuthorJerry Branson and Randy Roush A lifelong approach to engineering education can help restore the United States’ position as a global leader of technology. In the rapidly evolving landscape of engineering and technology, rethinking how science, technology, engineering, and mathematics (STEM) are taught over an ... An Interview with . . . Marv Goldschmitt, entrepreneur, AI analyst, and technological philosopher Thursday, June 12, 2025 AuthorMarv Goldschmitt RONALD LATANISION (RML): I’m happy to welcome Marv Goldschmitt to our Bridge interview series. This interview represents a bit of a departure from how we’ve done these interviews since they began 11 years ago. Historically, we have interviewed engineers who have done something in ...
President's Perspective: The Importance of Engineering and the NAE Monday, June 16, 2025 AuthorJohn L. Anderson Election to the National Academy of Engineering (NAE) is a great honor for any engineer. Yet, the purpose of our organization is not primarily honorific. The NAE exists to serve: to advance the welfare and prosperity of the nation by providing independent advice on matters involving engineering and ...
Guest Editors' Introduction: Advanced Biomanufacturing for Medicines Monday, June 16, 2025 AuthorBarry C. Buckland and Kelvin H. Lee In the fall of 2013, Professors Phillip A. Sharp and Robert Langer guest edited an issue of The Bridge on the theme of the Convergence of Engineering and the Life Sciences. The collection forecast the breadth in manufacturing approaches, capabilities, and innovation that would define the ...
Transforming Manufacturing to Continue Leading the Innovation of Biopharmaceuticals Monday, June 16, 2025 AuthorJ. Christopher Love Maintaining US leadership in the biomanufacturing sector requires investment in groundbreaking biomanufacturing technologies. Biopharmaceuticals have become essential medicines for preventing and treating diseases ranging from cancer and autoimmune disorders to neurological conditions, ...
Biopharmaceutical Manufacturing Platforms: Breaking Away from Our Past Monday, June 16, 2025 AuthorPaul C. Collins The new era of creativity and diversity of treatment modality in the biopharmaceutical industry has accelerated the need to adopt new platforms. “Platform” is a term that is often used in the biopharmaceutical manufacturing industry, but with different connotations and intentions ...
NIST Biomanufacturing Reference Materials: Development, Applications, and Impact Monday, June 16, 2025 AuthorKatharina S. Yandrofski, Megan H. Cleveland, Zvi Kelman, Mike J. Tarlov, and John P. Marino The NIST Biomanufacturing Program has made significant progress in antibody manufacturing and provides an approach to analytical measurements that can expedite the time to market of life-saving products and enable broader access to them. Monoclonal antibody (mAb) therapeutics, currently the ...
An Open-Access Platform: A NIIMBL Approach to Gene Therapy for Rare Diseases Friday, June 13, 2025 AuthorChris Williams, Eric Hacherl, Tim Charlebois, Erik Barton, Stephen Kaminsky, Brenna Kelley-Clarke, Angie Snell Bennett, Marco Th A promising model for gene therapy development is outlined that supports a thriving gene therapy community and increases access to therapies, particularly for patients with rare and ultra-rare diseases. Developing gene therapies for rare diseases faces significant challenges, including high ...
Shaping Future Supply Chains with Bioindustrial Manufacturing Friday, June 13, 2025 AuthorMelanie Tomczak and Penny Norquist Leveraging cutting-edge bioindustrial manufacturing technologies will enhance domestic supply chain resilience. From natural disasters and cyberattacks to growing sociopolitical tensions around the world, global supply chains are more unstable than any time in recent history. This instability ...
Revitalizing US Biomanufacturing to Strengthen the Global Supply and Security of Antibiotics Friday, June 13, 2025 AuthorMisti Ushio and Barry C. Buckland Renewed US investment in domestic antibiotic production is essential to ensure supply chain resilience and safeguard global health security. Antibiotics have significantly improved life expectancy and overall public health for over 80 years. The primary reasons antibiotics are critical for human ...
Synthetic Biology's Impact on Biopharmaceutical Manufacturing Friday, June 13, 2025 AuthorMruthula Rammohan, Akash Vaidya, Spencer Grissom, Rachel Silvestri, Christopher Pirner, Kevin Solomon, and Mark Blenner There is great potential for synthetic biology to improve biopharmaceutical manufacturing, but fully unleashing it requires technical innovation and solutions that address ethical, legal, security, and societal implications. Synthetic biology has already shown its usefulness in biopharmaceutical ...
Revolutionizing National STEM Education to BUILD a Future-Ready Workforce Thursday, June 12, 2025 AuthorJerry Branson and Randy Roush A lifelong approach to engineering education can help restore the United States’ position as a global leader of technology. In the rapidly evolving landscape of engineering and technology, rethinking how science, technology, engineering, and mathematics (STEM) are taught over an ...
An Interview with . . . Marv Goldschmitt, entrepreneur, AI analyst, and technological philosopher Thursday, June 12, 2025 AuthorMarv Goldschmitt RONALD LATANISION (RML): I’m happy to welcome Marv Goldschmitt to our Bridge interview series. This interview represents a bit of a departure from how we’ve done these interviews since they began 11 years ago. Historically, we have interviewed engineers who have done something in ...